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Cushing's Syndrome in Pets.

Cushing’s Syndrome in Pets.

Cushing’s Disease, a form of hyperadrenocorticism, is a chronic condition characterized by an excessive production of cortisol, a stress hormone, which can lead to a multitude of health issues for your beloved pet. The term “hyper” signifies an excess, and the overproduction of adrenocorticotropic hormone (ACTH) by the pituitary gland is the primary trigger for the adrenal glands to produce excessive amounts of cortisol.

Cushing’s syndrome can be attributed to various factors, including malfunctioning adrenal glands, pituitary gland abnormalities, toxin overload (often related to vaccinations), prolonged use of corticosteroids, and the impact of stress.

In its balanced state, cortisol plays a crucial role in regulating blood pressure and the proper metabolism of carbohydrates, fats, and proteins in the body. However, when cortisol levels remain elevated over an extended period, it results in unfavorable side effects, placing strain on organs and causing a decline in overall bodily functions.

Causes of Cushing’s Syndrome in Pets

Steroid-Induced (Iatrogenic) Cushing’s

Excessive use of cortisone products, including topical cortisone, can disrupt the normal feedback loop between the brain and the adrenal glands, eventually leading to the development of Cushing’s syndrome. Cortisone products elevate the levels of circulating cortisol in your pet’s system. This syndrome can be triggered by topical, injectable, and oral steroid treatments. In some instances, dogs may ingest topical steroids inadvertently from their owners’ use. A study even reported a case of a human using topical steroids on herself, resulting in the diagnosis of Cushing’s syndrome in her two dogs, who sadly passed away while she was using the steroids.

Adrenal-Dependent Hyperadrenocorticism (ADH)

Cushing’s syndrome can also stem from adrenal gland tumors that excessively produce cortisol. These tumors can be either benign (noncancerous) or malignant (cancerous). ADH tends to be more prevalent in large breed dogs compared to small breed dogs or cats, with female dogs being three times more susceptible than their male counterparts. Spayed females face a slightly higher risk than non-spayed ones.

Pituitary-Dependent Hyperadrenocorticism (PDH)

The majority of Cushing’s cases in pets result from dysfunction in the pituitary gland, which disrupts the balance of hormones released by the adrenal glands. The pituitary gland, often referred to as the master endocrine gland, is a small yet powerful structure located at the base of your pet’s brain, governing the function of the adrenal glands.

In cases of PDH Cushing’s disease, an enlarged pituitary gland, typically due to a benign tumor, prompts the overproduction of adrenocorticotropic hormone (ACTH). This, in turn, leads to excessive cortisol production by the adrenal glands. Stress can play a significant role in aggravating pituitary dysfunction in PDH cases.

Stress and its Role in Cushing’s

Notably, stress, whether physical (environmental) or emotional, can interfere with the optimal function of the endocrine system. Chronic stress results in the continuous release of stress hormones from the adrenal glands. This stress-induced cortisol production can contribute to the development of Cushing’s syndrome, further exacerbating your pet’s stress levels. It becomes a vicious cycle.

Eliminating factors such as excessive vaccination and minimizing exposure to man-made radiation, such as limiting x-ray procedures and keeping your pet away from 5G-related sources like cell phones and smart meters, can significantly reduce stress in your pet. This, in turn, helps prevent disruptions in the endocrine system, which could lead to Cushing’s syndrome.

Vaccinations and man-made electromagnetic fields (EMFs) have the potential to disrupt proper cell signaling, leading to dysregulation of the body’s defense mechanisms and altering hormonal signaling, which can contribute to tumor growth. Hormonal imbalances and disorders are frequently observed following vaccinations. Dr. Patricia Jordan has even suggested that a strong correlation exists between Cushing’s syndrome and heavy vaccination practices, stating, “I don’t see dogs with this disease that are not heavily vaccinated… or the offspring of heavily vaccinated parents.”

Breeds Prone to Cushing’s Syndrome

Certain dog breeds have been identified as having a heightened susceptibility to glandular issues, increasing their risk of developing Cushing’s Disease.

Please note that maintaining a nutritious, whole-food diet, incorporating herbal supplements, and minimizing exposure to toxins (such as limiting vaccinations) can aid in preventing undesirable genetic expressions, including those predisposing to glandular problems.

The at-risk breeds include:

  1. Beagle
  2. Boxer
  3. Poodle (all sizes)
  4. Boston Terrier
  5. Dachshund
  6. Staffordshire Terriers
  7. Yorkshire Terriers

Detecting Cushing’s Syndrome in Pets

Diagnosing Cushing’s Syndrome can be challenging because it often mimics other medical conditions. For instance, Sudden Acquired Retinal Degeneration (SARDS) can imitate Cushing’s and may also result from vaccination.

Accurate diagnosis is crucial to ensure your pet receives the appropriate treatment. Hormone level tests and assessments of adrenal gland function, along with a thorough evaluation of visible symptoms (listed below), are vital in confirming or ruling out Cushing’s. In pets suspected of having Cushing’s, a comprehensive blood panel and urinalysis may reveal the following indicators:

  • Elevated liver enzymes, including alkaline phosphatase (ALP), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT) levels
  • Increased blood glucose levels
  • Elevated neutrophil counts and decreased lymphocyte counts
  • Presence of protein in the urine
  • Low specific gravity of urine, often due to excessive water consumption

Common observable symptoms in pets with Cushing’s Syndrome include:

  • Excessive thirst and drinking
  • Frequent and copious urination
  • Heightened appetite
  • Restlessness
  • Persistent and heavy panting
  • Abdominal enlargement (caused by weakened abdominal muscles)
  • Enlarged liver
  • Hair loss, typically occurring bilaterally and easily shedding
  • Thinning and darkening of the skin, often on the undersides
  • Manifestation of diabetes-like symptoms
  • Altered reproductive cycles
  • Obesity, particularly with excess fat accumulation around the neck, shoulders, and abdomen
  • Recurrent urinary tract infections

It’s important to recognize that Cushing’s Disease can coexist with other chronic health issues and may indicate a further decline in overall health. For example, a dog that has suffered from skin allergies for years or has developed arthritis due to hip dysplasia or deteriorating knee joints may subsequently develop Cushing’s Disease. Dr. Pitcairn, DVM, suggests that Cushing’s may reflect a fundamental breakdown in your pet’s ability to regulate inflammation and repair tissues, processes in which the adrenal glands play a critical role.

Please note that a combination of visible symptoms and test results is necessary to determine the potential presence of Cushing’s Disease.

Natural Assistance for Cushing’s Syndrome

Providing natural support for pets dealing with Cushing’s Syndrome involves a comprehensive approach aimed at reducing stress (specifically cortisol levels), restoring hormonal balance, addressing liver health, nurturing the nervous system, and bolstering the well-being of the heart, adrenals, and kidneys.

Liver support is of paramount importance, as it plays a pivotal role in processing hormones and eliminating toxins that disrupt cellular function and hormonal equilibrium. The kidneys, situated atop the adrenals, work in tandem with them, making it essential to provide kidney support when dealing with adrenal imbalances, such as those seen in Cushing’s Syndrome. Elevated cortisol levels can lead to increased blood pressure and excessive stimulation of the nervous and cardiovascular systems, thereby placing strain on the heart.

Effective natural support for Cushing’s Syndrome encompasses several key components, including:

  1. Optimal Nutrition: A well-rounded, whole-food diet serves as the foundation for promoting the health of glandular tissues and facilitating the body’s optimal function to fend off diseases.
  2. Holistic Approaches: Incorporating homeopathic remedies, herbal supplements, and stress-reduction techniques like exercise and animal reiki are essential complementary treatments for managing Cushing’s Syndrome.

Herbal and Fungal Remedies for Cushing’s Disease

The following herbal and fungal allies can be beneficial for pets with Cushing’s Syndrome. It’s essential to select remedies that align with your pet’s unique condition rather than overwhelming them with an array of options. Customize your approach based on your pet’s individual circumstances.

Oak (Quercus robur) Phytoembryonic Therapy: Oak provides support for Cushing’s Syndrome by promoting balance in adrenal function and revitalizing pets experiencing fatigue and a weakened mental, physical, and emotional state. It can also aid in alleviating abdominal swelling and breathlessness resulting from excessive cortisol.

Note: Oak is a potent remedy and should be administered in small, pulsed doses—for example, two weeks on followed by two weeks off. To mitigate its bitter taste, consider adding 2-3 ml of water before administering the drops. For cats and extra-small dogs, dilute a drop with water and administer half to ensure they receive an appropriate dosage.

Suggested Dosages (Administer away from food, twice daily):

  • Extra-Small Dogs: 1 diluted drop
  • Small Dogs: 1 drop
  • Medium Dogs: 2 drops
  • Large Dogs: 3 drops
  • Extra-Large Dogs: 5 drops

Always consult with a qualified veterinarian or holistic practitioner before implementing natural remedies, ensuring that they are tailored to your pet’s specific needs and conditions.

Phytoembryonic Therapy with Judas Tree (Cercis siliquastrum)

Judas Tree offers invaluable support in cases of hormone imbalance, particularly when an excess of hormones is released, aiding in the restoration of hormonal equilibrium in pets dealing with Cushing’s Syndrome. It plays a pivotal role in pituitary gland support by mitigating excessive hormone signaling to the adrenals, thereby reducing stress. Furthermore, when an adrenal hemangioma is present, Judas Tree can provide much-needed relief. In cases of hyperadrenocorticism, which takes a toll on heart function, Judas Tree steps in as a protector, facilitating smooth blood circulation and preventing degeneration of arterial walls.

Judas Tree’s plant stem cell therapy proves particularly beneficial for pets with distended abdomens resulting from Cushing’s, often attributed to the weight gain associated with elevated cortisol levels.

Suggested Dosages (Administer away from food, twice daily):

  • Extra-Small Dogs: 1 drop
  • Small Dogs: 2 drops
  • Medium Dogs: 4 drops
  • Large Dogs: 6 drops
  • Extra-Large Dogs: 8 drops

Dandelion Root Tincture (Taraxacum officinale)

The liver plays a crucial role in hormone processing. For hormonal balance to be maintained, a healthy and fully functioning liver is essential. Dandelion root lends its support to both the liver and the endocrine system, contributing to overall well-being. In cases where Cushing’s is iatrogenic (caused by pharmaceuticals), Dandelion root can assist in the body’s detoxification process.

Note: Dandelion is not recommended for pets with gallstones or gallbladder infections.

Suggested Dosages (Administer away from food, twice daily):

  • Extra-Small Dogs: 1 drop
  • Small Dogs: 3 drops
  • Medium Dogs: 5 drops
  • Large Dogs: 7 drops
  • Extra-Large Dogs: 10 drops

Astragalus Tincture (Astragalus membranaceus)

Astragalus assumes a multifaceted role in supporting pets with Cushing’s Syndrome. It aids in modulating the immune system, fortifying the cardiovascular system, bolstering adrenal gland function, reducing stress, and even possesses anti-tumor properties. This makes Astragalus a comprehensive remedy for managing the complexities of Cushing’s.

Suggested Dosages (Administer away from food, twice daily):

  • Extra-Small Dogs: 1 drop
  • Small Dogs: 3 drops
  • Medium Dogs: 5 drops
  • Large Dogs: 7 drops
  • Extra-Large Dogs: 10 drops

Burdock Root Tincture (Arctium lappa)

Burdock root offers support to the liver, contributing to healthier skin and coat in pets experiencing hair loss and thinning skin due to Cushing’s. Additionally, it stimulates kidney function, aiding the body’s detoxification processes. Balancing fats and oils in the body is another role Burdock plays, which is significant in hormone regulation, given that hormones, including cortisol, are fat-soluble.

Note: Burdock tincture (alcohol extraction) should be administered for no more than eight weeks at a time, followed by at least an eight-week break before resuming.

Suggested Dosages (Administer away from food, twice daily):

  • Extra-Small Dogs: 1 drop
  • Small Dogs: 3 drops
  • Medium Dogs: 5 drops
  • Large Dogs: 7 drops
  • Extra-Large Dogs: 10 drops

Chaste Tree Tincture (Vitex-agnus-castus)

Chaste tree can enhance the mood of pets with low spirits and reduced energy, potentially reducing abnormal fat deposition associated with Cushing’s Syndrome. In cases where spaying has occurred, Chaste tree may be especially beneficial, as it can help address changes in the reproductive cycle caused by Cushing’s disease. Spaying can disrupt natural hormone regulation, setting off a chain reaction affecting other hormones.

Suggested Dosages (Administer away from food, twice daily):

  • Extra-Small Dogs: 1 drop
  • Small Dogs: 4 drops
  • Medium Dogs: 8 drops
  • Large Dogs: 10 drops
  • Extra-Large Dogs: 13 drops

Ashwagandha Root Powder (Withania somnifera)

Ashwagandha plays a pivotal role in helping pets cope with stress, acting as a protector for the adrenals. It aids in the prevention of Cushing’s and promotes overall vitality in pets grappling with the condition. This remedy is particularly beneficial for pets experiencing restlessness or anxiety due to elevated cortisol levels. Ashwagandha also influences thyroid hormone levels by reducing cortisol, thereby fostering glandular health and calming the nervous system.

Suggested Dosages (Administer mixed into food, twice daily):

  • Extra-Small Dogs: 1/4 tsp
  • Small Dogs: 1/2 tsp
  • Medium Dogs: 1 tsp
  • Large Dogs: 1 1/2 tsp
  • Extra-Large Dogs: 2 tsp

Maidenhair Tree Tincture (Gingko biloba)

Rich in antioxidants, Maidenhair Tree promotes circulation, particularly cerebral (brain) circulation. It may help reduce corticosteroid levels in pets that seem to be experiencing cognitive decline due to Cushing’s.

Suggested Dosages (Administer away from food, twice daily):

  • Extra-Small Dogs: 1 drop
  • Small Dogs: 3 drops
  • Medium Dogs: 6 drops
  • Large Dogs: 9 drops
  • Extra-Large Dogs: 12 drops

Always seek guidance from a qualified veterinarian or holistic practitioner when considering natural remedies for your pet’s specific needs and conditions.


Milk Thistle Seeds (Silybum marianum)

Milk Thistle, a potent ally in supporting the liver, a vital organ for hormone processing, plays a pivotal role in enhancing hormone regulation. It proves invaluable in addressing liver stagnation caused by excessive toxins, such as those found in vaccines, which can disrupt hormonal balance. By stimulating both the liver and kidneys, Milk Thistle aids in processing and expelling toxins from the body. Furthermore, it offers hepatoprotective properties, shielding the liver from potential damage, especially relevant in cases of excess cortisol associated with Cushing’s Syndrome, which can lead to fatty liver.

Suggested Dosages (Administer mixed into food, twice daily):

  • Extra-Small Dogs: 1/4 tsp
  • Small Dogs: 1/2 tsp
  • Medium Dogs: 1 tsp
  • Large Dogs: 1 1/2 tsp
  • Extra-Large Dogs: 2 tsp

Stinging Nettles Infusion (Urtica dioica)

Stinging Nettles infusion is a nutritional powerhouse, enriched with vitamins, minerals, and chlorophyll, serving as a robust supporter of blood, kidney, and adrenal health. Given the interdependent relationship between the adrenals and kidneys, this infusion proves especially beneficial. To create a Nettles infusion, pour almost boiling water over one tablespoon of dried herb or two tablespoons of fresh herb, allowing it to steep for a minimum of two hours to extract the maximum benefits. You can either strain the infusion or serve both the liquid and the leaves directly into your pet’s food twice daily.

Suggested Infusion Dosages:

  • Extra-Small Dogs: 1 tsp
  • Small Dogs: 2 tsp
  • Medium Dogs: 1 1/2 tbsp
  • Large Dogs: 2 tbsp
  • Extra-Large Dogs: 2 1/2 tbsp

Shiitake Mushroom (Lentinula edodes)

Shiitake Mushroom proves highly beneficial, particularly in cases involving cancer or tumors affecting the pituitary or adrenal glands. It plays a pivotal role in promoting healthy blood circulation, supporting heart health, and regulating cortisol levels. Shiitake mushroom also aids in mitigating the side effects of radiation exposure, offering support to pets continuously exposed to man-made electromagnetic fields (EMFs) as a preventive measure against Cushing’s. When utilizing tinctures, it’s optimal to select those that are double or triple extracted to ensure the maximum concentration of beneficial constituents.

Suggested Dosages (Administer away from food, twice daily):

  • Extra-Small Dogs: 2 drops
  • Small Dogs: 3 drops
  • Medium Dogs: 7 drops
  • Large Dogs: 11 drops
  • Extra-Large Dogs: 15 drops

Chaga Mushroom (Inonotus obliquus)

Chaga Mushroom is particularly well-suited for pets facing Cushing’s due to malignant tumors. It boasts an exceptional antioxidant content and contributes to the relaxation of the nervous system while concurrently reducing cortisol levels.

Note: Chaga is an endangered species and regrows over hundreds of years. When foraging Chaga, adhere to sustainable practices by harvesting no more than a quarter of the Chaga growth on a Birch tree. If purchasing Chaga, ensure it is ethically sourced and use it only if well-indicated for your pet’s specific condition.

Suggested Dosages (Administer away from food, twice daily):

  • Extra-Small Dogs: 1 drop
  • Small Dogs: 3 drops
  • Medium Dogs: 6 drops
  • Large Dogs: 9 drops
  • Extra-Large Dogs: 12 drops

For large-sized pets with life-threatening malignant tumors, Chaga can be administered at doses of up to six grams daily.

Homeopathic Approaches to Address Cushing’s Syndrome

There are two homeopathic options for managing Cushing’s Syndrome: homeopathic organotherapy, which involves remedies derived from animal tissues to modulate your pet’s cortisol production, and the following remedies, which do not involve animal tissue.

For the homeopathic remedies listed below, administer two pellets into your pet’s cheek two to three times daily, ensuring they are taken away from food, either 30 minutes before a meal or two hours after eating. Even if your pet spits out the pellet, rest assured that they have received the necessary dose, provided the remedy contacted their mucus membranes.

Note: When handling homeopathic remedies, avoid touching them with your hands. Utilize the dispenser cap to dispense the pellets, emptying them directly from the cap into your pet’s cheek.

Arsenicum 30C or 200C Arsenicum is a suitable choice if your pet exhibits symptoms such as a swollen and painful abdomen, an enlarged liver, skin eruptions, fatigue, and increased thirst.

Hepar 30C If your pet’s skin shows signs of vulnerability, becoming prone to infections or developing bumps, and is accompanied by an enlarged liver and a distended abdomen, Hepar may be the appropriate remedy.

Mercurius 30C Mercurius is a recommended remedy for pets experiencing muscle weakness, digestive issues, burping, coordination difficulties, excessive hunger and thirst, skin eruptions, and an enlarged liver due to Cushing’s Syndrome.

Sulphur 30C Sulphur is indicated when Cushing’s Syndrome is accompanied by symptoms such as depression, weakness, frequent urination (particularly at night), chronic skin eruptions, and increased thirst in your pet.

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